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Daily briefing: Adults with sickle-cell disease...

NATURE BRIEFING.10 September 2021 .Daily briefing: Adults with sickle-cell disease are being left behind .Medical advances have slashed the death rate for children with sickle-cell disease in the US — but mortality for adults has grown steadily worse. Plus, CRISPR-like enzymes have been found in microbes, and a fossil predator was a giant ‘swimming head’.Flora Graham .Flora Graham View author publications You can also search for this author in PubMed ?Google ScholarShare on Twitter . Share on Twitter . Share on Facebook . Share on Facebook . Share via E-Mail . Share via E-Mail .Sign up for Nature BriefingYou have full access to this article via your institution. Download PDF Hello Nature readers, would you like to get this Briefing in your inbox free every day? Sign up here.Hurricane Ida destroyed almost 30,000 utility poles. Some Louisiana residents could be without power for up to a month. Credit: Nick Wagner/Xinhua/eyevine After Ida, researchers rethink their future . Hurricane Ida was the sixth tropical cyclone to make landfall in Louisiana since the start of 2020, and scientists are worried that the frequency of the storms, combined with a failure by state and local officials to adapt infrastructure to climate change, will imperil the millions of people who live along the Louisiana coast. Researchers are also contemplating how much more disruption the practice of science in the region can weather . “I would not be surprised if some students don’t come back, and faculty that might be nearing retirement may be deciding this is the straw that broke the camel’s back,” says microbial ecologist Keith Clay. Nature 6 min read CRISPR-like enzymes found in microbes . The search for a CRISPR enzyme’s ancestors has revealed more than one million potential genome-editing tools . Researchers found the RNA-targeted enzymes capable of cutting DNA among a family of proteins called IscB. These proteins are thought to be the ancestors of the enzyme Cas9 — known as CRISPR’s molecular scissors. Nature 4 min read Reference:Science paper Fossil predator was a giant ‘swimming head’ . A half-metre-long arthropod that prowled the Cambrian seas half a billion years ago was mostly head. Titanokorys gainesi , whose head takes up nearly half the length of its body , was covered in a domed, spiked carapace. Its eyes were on its back and faced straight up — for spotting other predators, not prey. “Predation was a big evolutionary innovation that happened during the Cambrian,” says paleontologist Jean-Bernard Caron. “Here, we are illustrating the complexity of that.” Science 4 min read Reference:Royal Society Open Science paper Podcast series . Hope lies in dreams .Nature Biotechnology has launched a ten-part podcast series that looks at the astonishing life and work of pioneering biotech researcher Stan Crooke . After decades of struggle and years of public doubt, his company eventually developed the first drug to treat a devastating childhood degenerative disease called spinal muscular atrophy. The first episode looks at “an ugly place” — Crooke’s impoverished and difficult childhood, and when it began to take a turn for the better. Nature Biotechnology 32 min listen BACKSTORY: FROM THE REPORTER’S PERSPECTIVE .I first learnt of Stan’s background while interviewing him at a biotech conference in 2015. He told me he’d begun his life squatting in a tar-paper shack in Indianapolis, and to this day he’s not fully sure of his real birthday. From these humble beginnings, he became a ground-breaking scientist and a champion for a brand new drug modality — antisense. It’s an amazing life, and an incredible story. The podcast is the result of more than two years of reporting, and we hope you enjoy it. It can be found here , and wherever you get your podcasts. Brady Huggett, Senior editor Features & opinion .Adults with sickle-cell disease left behind . Medical advances to treat sickle-cell disease have slashed the death rate for children in the United States — but mortality for adults has grown steadily worse since 1979. The difference cannot be fully explained by biology. Many of the interventions that save children’s lives can save adult lives, too, but they are rarely used. And most people in the US with the disease are Black, and Black adults encounter racism in the medical system in a way that children mostly do not. Nature 11 min read This feature is part of Nature Outlook: Sickle-cell disease , an editorially independent supplement produced with the financial support of CSL Behring.Futures: science fiction from Nature . In this week’s helping of short stories for Nature ’s Futures series:? Dive into some fascinating literary selections in ‘ Five books from the Alnif Crater travelling library ’.? Guilt, friendship and technology combine in ‘ The world in a bottle ’ Podcast: Earth’s missing billion years . This week, the Nature Podcast features three fascinating stories that were recently highlighted in the Briefing . A period of one billion years is missing from the geological record — and researchers are trying to work out where it went. Leaded petrol has been banned in Algeria, meaning that the toxic fuel is no longer legally available for cars anywhere in the world. And ancient artefacts from Saudi Arabia, which correspond to five periods of occupation during brief ‘green’ windows of reduced aridity, reveal more about this key migratory crossroads for ancient humans. Nature Podcast 13 min listen Subscribe to the Nature Podcast on Apple Podcasts , Google Podcasts or Spotify . Quote of the day . “Perhaps the reason I pursued an academic career, despite the mental and physical tolls of this profession, has all along been to achieve a kind of generational vindication of what my father endured way back then.” . Sound-studies researcher Neil Verma shares the story of how racism in Canada smothered his father’s promising palaeontology career. ( Twitter thread 2 min read ) doi: https://doi.org/10.1038/d41586-021-02498-3Today Leif Penguinson is scaling a limestone gorge abutting Dents de Lanfon mountain in France. Can you find the penguin ?The answer will be in Monday’s e-mail, all thanks to Briefing photo editor and penguin wrangler Tom Houghton.This newsletter is always evolving — tell us what you think! Please send your feedback to briefing@nature.com . Flora Graham, senior editor, Nature Briefing Related Articles . Daily briefing: Ground-breaking carbon capture plant starts up . Daily briefing: Made-up words communicate across cultures . Daily briefing: These tuna species are no longer endangered . Daily briefing: These tuna species are no longer endangered . .Jobs .Editor-in-Chief - Inside Precision Medicine . GEN (Genetic Engineering & Biotechnology News) New Rochelle, NY, United States B2B Marketing Manager . GEN (Genetic Engineering & Biotechnology News) New Rochelle, United States Postdoctoral Fellow Ion Channel Structure and Function . Van Andel Research Institute (VAI) Grand Rapids, MI, United States Multiple postdoctor positions in drug discovery . The University of Arizona (Arizona) tucson, AZ, United States .