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发布日期: Jul 17, 2019
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Engineering of exosomes: Steps towards green production of drug delivery systems | Bentham Science

Engineering of exosomes: Steps towards green production of drug delivery systems. (E-pub Abstract Ahead of Print)Author(s): Abdelrahman Y. Sherif, Kayyali Chair for Pharmaceutical Industry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia Gamaleldin I. Harisa, Kayyali Chair for Pharmaceutical Industry, College of Pharmacy, King Saud University, Riyadh, Saudi ArabiaFars K. Alanazi, Kayyali Chair for Pharmaceutical Industry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia Abdullah M.E. Youssof. Kayyali Chair for Pharmaceutical Industry, College of Pharmacy, King Saud University, Riyadh, Saudi ArabiaAffiliation:Journal Name: Current Drug Targets DOI : 10.2174/1389450120666190715104100  Journal HomeAbstract: . Although many drug delivery systems have been developed to achieve excellent drug therapeutic index ,however, most of these systems still have biocompatibility problems as well as they cause environmental pollution. Therefore, exosomes as biological carries are considered as biocompatible, biodegradable and safe to the environment in comparison with synthetic drug delivery systems. Biologically, exosomes are considered as natural cargoes for bioactive material as well as they involved in the transport of cellular signaling and communications. In respect to biological origin of exosomes, they could be produced by top down techniques of cell engineering. Hence they are considered as green drug delivery system without environmental hazard. In this regards, exosomes are considered as promising drug delivery systems. This review highlights exosome as green drug delivery systems engineering, isolation, characterization, application and limitations. Keywords: Drug targeting, Biological DDS, Green DDS, Exosome, Bionanocarriers, vesicular carrier. Rights & PermissionsPrintExport Cite as× Current Drug Targets. Title:Engineering of exosomes: Steps towards green production of drug delivery systems VOLUME: 20 Author(s):Abdelrahman Y. Sherif, Gamaleldin I. Harisa, Fars K. Alanazi and Abdullah M.E. Youssof Affiliation:Kayyali Chair for Pharmaceutical Industry, College of Pharmacy, King Saud University, Riyadh, Kayyali Chair for Pharmaceutical Industry, College of Pharmacy, King Saud University, Riyadh, Kayyali Chair for Pharmaceutical Industry, College of Pharmacy, King Saud University, Riyadh, Kayyali Chair for Pharmaceutical Industry, College of Pharmacy, King Saud University, Riyadh Keywords:Drug targeting, Biological DDS, Green DDS, Exosome, Bionanocarriers, vesicular carrier. Abstract:Although many drug delivery systems have been developed to achieve excellent drug therapeutic index ,however, most of these systems still have biocompatibility problems as well as they cause environmental pollution. Therefore, exosomes as biological carries are considered as biocompatible, biodegradable and safe to the environment in comparison with synthetic drug delivery systems. Biologically, exosomes are considered as natural cargoes for bioactive material as well as they involved in the transport of cellular signaling and communications. In respect to biological origin of exosomes, they could be produced by top down techniques of cell engineering. Hence they are considered as green drug delivery system without environmental hazard. In this regards, exosomes are considered as promising drug delivery systems. This review highlights exosome as green drug delivery systems engineering, isolation, characterization, application and limitations.Close Print this page ×Export File: RIS (for EndNote, Reference Manager, ProCite) BibTeX TextContent: Citation Only Citation and Abstract Close× About this article. Cite this article as: Abdelrahman Y. Sherif, Gamaleldin I. Harisa, Fars K. Alanazi and Abdullah M.E. Youssof, “Engineering of exosomes: Steps towards green production of drug delivery systems”, Current Drug Targets (2019) 20: 1. https://doi.org/10.2174/1389450120666190715104100 DOI https://doi.org/10.2174/1389450120666190715104100. Print ISSN 1389-4501. Publisher Name Bentham Science Publisher. Online ISSN 1873-5592. About this journalClose Article Details (E-pub Abstract Ahead of Print) DOI: 10.2174/1389450120666190715104100 Price: $95 Journal Insight .