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Nature Reviews Drug Discovery
Latest Reviews & Analysis . Emerging therapeutic opportunities for integrin inhibitors .Integrins are key signalling molecules that are present on the surface of subsets of cells and are therefore good potential therapeutic targets. In this Review, Hatley and colleagues discuss the development of integrin inhibitors, particularly the challenges in developing inhibitors for integrins that contain an αv-subunit, and suggest how these challenges could be addressed.R. J. Slack.S. J. F. Macdonald.R. J. D. Hatley. Review Article 17 Sept 2021 Advances in TRP channel drug discovery: from target validation to clinical studies .This Review discusses recent findings in transient receptor potential (TRP) channel structural biology and the impact of these findings in drug development and clinical indications. It also addresses the challenges of modulating TRP channels and the need for targeted approaches to minimize potential side-effects due to the multifunctional roles of TRP channels.Ari-Pekka Koivisto.Maria G. Belvisi.Arpad Szallasi. Review Article 15 Sept 2021 mRNA vaccines for infectious diseases: principles, delivery and clinical translation .The COVID-19 pandemic has established mRNA vaccines as a rapid, effective and safe approach for the protection of individuals from infectious disease. Here, Whitehead and colleagues review the principles of mRNA vaccine design, synthesis and delivery, assessing recent progress and key issues in the development of mRNA vaccines for a range of infectious diseases.Namit Chaudhary.Drew Weissman.Kathryn A. Whitehead. Review Article 25 Aug 2021 Atopic dermatitis: an expanding therapeutic pipeline for a complex disease .Recent advances in understanding of the complex phenotype and mechanisms underlying atopic dermatitis (AD) have revealed multiple new potential targets for pharmacological intervention. Here, Bieber reviews therapeutic strategies and assesses the expanding pipeline for the therapy of AD, highlighting the potential for a precision medicine approach to the management of this complex disorder.Thomas Bieber. Review Article 20 Aug 2021 Engineering islets from stem cells for advanced therapies of diabetes .Diabetes is a substantial and increasing health concern. In this Review, Lickert and colleagues discuss the progress made in developing insulin-producing islets using in vitro methods, including which aspects need to be improved in order to use these islets as transplants. Using these islets in laboratory settings could further our understanding of pancreatic function and the mechanisms underlying diabetes.Johanna Siehler.Anna Karolina Bl?chinger.Heiko Lickert. Review Article 10 Aug 2021Trends in kinase drug discovery: targets, indications and inhibitor design . Misty M. Attwood.Doriano Fabbro.Helgi B. Schi?th. Review Article 05 Aug 2021 Immune-related toxicities of checkpoint inhibitors: mechanisms and mitigation strategies . Ryan J. Sullivan.Jeffrey S. Weber. Review Article 27 Jul 2021 The PROTACtable genome . Melanie Schneider.Chris J. Radoux.Andrew R. Leach. Perspective 20 Jul 2021 The glomerular filtration barrier: a structural target for novel kidney therapies . Ilse S. Daehn.Jeremy S. Duffield. Review Article 14 Jul 2021 .
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