Several naturally discovered or laboratory-synthesized pyrrole compounds have insecticidal, acaricidal and microbial properties. The novel sulfanyl 5H-dihydro-pyrrole derivatives exhibit certain antioxidant activities. However, there is a knowledge gap whether these substances are potent grain protectants against stored-product insect pest species. In this context, we evaluated the insecticidal activity of five novel pyrrole derivatives (under the trivial names 3a, 3g, 3l, 3m, 3h), against larvae of Tribolium confusum Jaquelin du Val and Ephestia kuehniella Zeller at different doses (0.1, 1 and 10?ppm), exposure intervals (7, 14 and 21?days or 1, 2, 7, 14, 21?days), temperatures (20, 25 and 30?°C), relative humidity (RH) (55 and 75?%) levels and commodities (wheat, maize, barley). The pyrrole derivative 3a exhibited the highest insecticidal activity, while 3g, 3l, 3m and 3h caused similar mortality against larvae of T. confusum. Apart of the level of efficacy, all tested pyrrole derivatives performed similarly according temperature. We found that increase in temperature increased mortality in the majority of the tested combinations. Generally, the pyrrole derivatives caused the highest mortality levels at 30?°C. The pyrrole derivatives 3a, 3g, 3l and 3m were affected by relative humidity at almost all combinations tested. The 75?% level of RH moderated the efficacy of the pyrrole derivatives, while the 55?% enhanced it. Mortality of T. confusum and E. kuehniella on maize was much lower on treated maize than barley or wheat. However, 100?% control of both species was recorded only on treated barley. The results of the present study indicate that the pyrrole derivatives tested could serve as grain protectants against noxious stored-product insects under certain biotic and abiotic conditions.