This document is a supplement to the President’s 2012 Budget Request submitted to Congress in February of 2011. It gives a description of the activities underway in 2010 and 2011 and planned for 2012 by the Federal Government agencies participating in the National Nanotechnology Initiative (NNI), primarily from a programmatic and budgetary perspective. It is based on the NNI Strategic Plan released in February 2011 and reports actual investments for 2010, estimated investments for 2011 and requested investments for 2012 by program component area (PCA), as called for under the provisions of the 21st Century Nanotechnology Research and Development Act (Public Law 108-153).