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This document is intended to provide an overview of progress on the coordinated implementation of the 2011 NNI Environmental, Health, and Safety (EHS) Research Strategy that was developed by the NSET Subcommittee’s Nanotechnology Environmental and Health Implications (NEHI) Working Group. The 2011 NNI EHS Research Strategy aims to ensure the responsible development of nanotechnology by providing guidance to the Federal agencies that produce the scientific information for risk assessment, risk management, regulatory decision making, product use, research planning, and public outreach. It describes the NNI’s EHS vision and mission, the state of the science, and the research needed to achieve the vision.